Ubiquitination of the PI3-kinase VPS-34 promotes VPS-34 stability and phagosome maturation
نویسندگان
چکیده
منابع مشابه
The VPS-34 PI3 kinase negatively regulates RAB-5 during endosome maturation
The Rab5 GTPase and phosphatidylinositol-3 phosphate (PI(3)P) coordinately regulate endosome trafficking. Rab5 recruits Vps34, the class III PI3-kinase (PI3K), to generate PI(3)P and recruit PI(3)P binding proteins. Loss of Rab5 and loss of Vps34 have opposite effects on endosome size suggesting that our understanding of how Rab5 and PI(3)P cooperate is incomplete. Here we report a novel regula...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2017
ISSN: 0021-9525,1540-8140
DOI: 10.1083/jcb.201705116